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. 2018 May 5;96(6):483–493. doi: 10.1007/s00109-018-1640-y

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Cryo-EM structures of filamentous proteins and their biomedical relevance. (A) Tobacco mosaic virus is one of the most widespread viruses around the world, being a prime example for plant pathogens that can have far-reaching consequences for the economy as well as food supply. [EMD-2842]. (B) Microtubules are not only core components of the cytoskeleton, but are also essential in axonal transport along neurons, constituting the track for cargo-transporting motor proteins. [EMD-8322]. (C) Tau filaments are neurodegenerative deposits that are found in the brains of AD patients. [EMD-3741]. (D) The interaction of F-actin and myosin filaments is responsible for muscle contraction. Malfunctions can cause myopathies. [EMD-8165]