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Siglec-9 blockade restores cytokine secretion and degranulation of NK cells in chronic hepatitis B (CHB) patients. PBMCs from CHB patients pretreated with Siglec-9 blocking antibody or isotype control IgG were stimulated with PMA plus ionomycin. Then, the expression of IFN-γ (A), TNF-α (B), and CD107a (C) were analyzed by flow cytometry. The right panels showed the representative flow cytometry data from one subject.
