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. 2018 May 30;9:1058. doi: 10.3389/fmicb.2018.01058

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Copyright © 2018 Markley and Wencewicz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Victim of fate: the site of tetracycline oxidation is determined by binding mode and distance from flavin-C4a. Bond distances to reactive centers on CTc bound to TetX in Mode I_D,A (PDB ID: 2y6r) and CTc bound to Tet50 in Mode II_A,D (PDB ID: 5tui) were determined in PyMOL from the corresponding PDB files. Images of FAD were generated using PyMOL v1.7.