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. 2018 May 30;12:149. doi: 10.3389/fncel.2018.00149

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Copyright © 2018 Hayani, Song and Dityatev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased frequency of action-potential independent miniature EPSCs (mEPSCs) onto fast-spiking interneurons 7 days (7 d) after ChABC injection. Representative traces (A), amplitude (B), frequency (C), rise (D) and decay time (E) of mEPSCs in FSIs after Vehicle (n = 9) or ChABC (n = 9) treatments. (F) Graph representing VGluT1 expression in the perisomatic region of parvalbumin (PV)-expressing FSIs. Scale bar, 5 μm. (G) Perisomatic puncta density (number of puncta/10 μm of soma perimeter) after treatment with Vehicle (33 neurons from three mice) or ChABC (39 neurons from three mice). Bars represent mean ± SEM values (per animal) in vehicle- (black) and ChABC-treated (white) groups. **P < 0.01, t-test, compared with vehicle.