Table 3.
Patient demographics, hemodynamic parameters, cardiac function and ECV for BAV patients for all subgroups
| Patient subcohorts | AS/AR | no AS/AR | p-values | |||
|---|---|---|---|---|---|---|
| AS | AR | AS + AR | ||||
| number | 35 | 7 | 16 | 12 | 14 | |
| age (years) | 52.0 ± 13.8 | 59.6 ± 10.8 | 50.1 ± 12.5 | 50.1 ± 16.3 | 45.8 ± 12.1 | * 0.13; † 0.02; ‡ 0.35; § 0.46 |
| Gender (male/female) | 22/13 | 3/4 | 8/8 | 14/1 | 8/6 | |
| diameter mid AAo (cm) | 4.2 ± 0.7 | 4.1 ± 0.6 | 4.0 ± 0.8 | 4.4 ± 0.6 | 3.7 ± 0.8 | * 0.06; † 0.22; ‡ 0.30; § 0.015 |
| Hemodynamic Parameters | ||||||
| Peak systolic velocity (m/s) | ||||||
| AAo | 2.87 ± 1.12 | 3.21 ± 0.56 | 1.95 ± 0.36 | 3.91 ± 1.02 | 1.70 ± 0.22 | * <0.001; † <0.001; ‡ 0.03; § <0.001 |
| arch | 1.47 ± 0.45 | 1.51 ± 0.51 | 1.25 ± 0.33 | 1.73 ± 0.45 | 1.09 ± 0.21 | * <0.001; † 0.07; ‡ 0.13; § <0.001 |
| DAo | 1.25 ± 0.31 | 1.13 ± 0.34 | 1.24 ± 0.30 | 1.32 ± 0.31 | 1.18 ± 0.23 | * 0.74; † 0.77; ‡ 0.54; § 0.19 |
| Peak systolic WSS (N/m2) | ||||||
| AAo | 0.78 ± 0.22 | 0.83 ± 0.13 | 0.66 ± 0.16 | 0.92 ± 0.24 | 0.60 ± 0.10 | * <0.001; † 0.003; ‡ 0.28; § <0.001 |
| arch | 0.66 ± 0.17 | 0.62 ± 0.23 | 0.63 ± 0.17 | 0.73 ± 0.13 | 0.63 ± 0.15 | * 0.50; † 0.92; ‡ 0.98; § 0.09 |
| DAo | 0.69 ± 0.17 | 0.66 ± 0.20 | 0.70 ± 0.19 | 0.70 ± 0.14 | 0.69 ± 0.19 | * 0.98; † 0.72; ‡ 0.89; § 0.86 |
| Cardiac Function and ECV | ||||||
| ECV (%) | 26.2 ± 2.4 | 26.2 ± 2.0 | 26.1 ± 2.3 | 26.3 ± 3.0 | 25.2 ± 3.7 | * 0.58; † 0.44; ‡ 0.45; § 0.42 |
| EDVI (ml/m2) | 81.6 ± 31.2 | 65.1 ± 12.9 | 89.9 ± 38.6 | 80.7 ± 25.4 | 70.7 ± 16.7 | * 0.13; † 0.41; ‡ 0.09; § 0.27 |
| ESVI (ml/m2) | 31.5 ± 14.4 | 21.9 ± 4.4 | 35.2 ± 15.6 | 32.6 ± 14.8 | 26.7 ± 7.9 | * 0.15; † 0.09; ‡ 0.07; § 0.25 |
| SVI (ml/m2) | 50.1 ± 18.9 | 43.3 ± 9.5 | 54.8 ± 24.1 | 48.1 ± 14.4 | 44.1 ± 9.6 | *0 .16; † 0.85; ‡ 0.19; § 0.44 |
| LVmass index (g/m2) | 80.1 ± 21.0 | 67.3 ± 10.5 | 78.6 ± 24.3 | 90.4 ± 16.8 | 60.6 ± 8.0 | * <0.001; † 0.17; ‡ 0.01; § <0.001 |
| EF (%) | 61.9 ± 6.2 | 66.2 ± 4.5 | 59.6 ± 6.4 | 60.5 ± 7.9 | 62.6 ± 3.9 | * 0.69; † 0.09; ‡ 0.13; § 0.43 |
AS=aortic valve stenosis, AR= aortic valve regurgitation, AAo=ascending aorta, DAo=descending aorta, EDVI=end-diastolic volume indexed to BSA, ESVI=end-systolic volume indexed to BSA, SVI=stroke volume indexed to BSA, LV=left ventricular, EF=ejection fraction.
*
Comparison AS/AR and no AS/AR,
†
comparison AS and no AS/AR,
‡
comparison AR and no AS/AR,
§
comparison AS+AR and no AS/AR; significant differences are printed in bold and italics.