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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Matrix Biol. 2017 Dec 5;71-72:90–99. doi: 10.1016/j.matbio.2017.11.014

Table 1.

LTBP-Dependent Phonotypes

Name Mouse Human
LTBP-1 In Vivo Persistent Truncus Arteriosis
Interrupted aortic arch		 Non reported
In Vitro Anti-LTBP-1 antibody blocks ES cell differentiation to endothelial cells
LTBP-2 Lens Luxation In Vivo Primary Congenital glaucoma, Microspherophakia.
LTBP-3 In Vivo Cranial facial and dental malformations.
Premature cranial synchondroses ossification		 In Vivo Acromeric and geleophysic dysplasia.
Enamel abnormalities
LTBP-4 In Vivo Defective elastogenesis in lung, cardiomyopathy, impaired lung development at the secular phase
Modulation of muscular dystrophy phenotype.		 In Vivo Loss associated with enhances AAA growth.
Decrease alveolar septation in the alveolar phase.
Certain alleles enhance or diminish muscular dystrophy Phenotype.