Table 1.

Top SNP associations with major depression in full cohort and subgroups.

		rs ID	rs7526682	rs11577545	rs950893	rs12415800	rs35936514
		Chr	1	1	8	10	10
		Position	211973950	226799083	23450510	69624180	126244970
		Major/Mino r Alleles	C/G	C/T	A/G	G/A	C/T
Linear mixed model (BOLT-LMM)	Full cohort	MAF	0.13	0.22	0.28	0.46	0.26
		P-value	4.1×10−5	3.2×10−5	1.9×10−6	5.1×10−7	1.8×10−6
		z score	4.10	4.16	−4.76	5.02	−4.78
	No adversity	MAF	0.13	0.21	0.28	0.46	0.26
		P-value	3.0×10−8	3.1×10−8	6.9×10−9	3.2×10−6	8.7×10−5
		z score	5.54	5.54	−5.79	4.66	−3.93
	Adversity	MAF	0.13	0.23	0.27	0.45	0.27
		P-value	3.8×10−1	9.4×10−2	8.2×10−2	6.0×10−2	2.50×10−3
		z score	−0.89	−1.67	0.82	1.88	−3.03
Logistic regression (PLINK)	Full cohort	P-value	3.7×10−5	9.0×10−5	6.9×10−7	9.6×10−7	1.5×10−6
		odds ratio	1.19	1.15	0.85	1.15	0.85
		CI	1.10–1.30	1.07–1.23	0.80–0.91	1.09–1.22	0.80–0.91
	No adversity	P-value	4.6×10−8	8.0×10−8	2.1×10−9	2.9×10−6	8.8×10−5
		odds ratio	1.31	1.25	0.79	1.17	0.86
		CI	1.19–1.45	1.15–1.36	0.74–0.86	1.10–1.26	0.80–0.93
	Adversity	P-value	3.7×10−1	9.7×10−2	4.6×10−1	5.1×10−2	2.0×10−3
		odds ratio	0.93	0.90	1.05	1.12	0.82
		CI	0.78–1.10	0.79–1.02	0.92–1.19	1.00–1.25	0.72–0.93

This table reports the test statistics at the SNPs associated with major depression in the subgroup unexposed to adversity a) in the full cohort, b) in the subgroup unexposed to adversity (No Adversity) and c) adversity-exposed (Adversity); the minor allele at each SNP is the tested allele. Results from leave-one-chromosome-out linear mixed model association testing in BOLT-LMM and logistic regression with 10 principal components as covariates in PLINK are shown. SNPs showing genome-wide significant associations are shown in bold. Two SNPs (rs12415800 and rs35936514) showing genome wide significant association with major depression in our previous analysis of all samples in CONVERGE (including those without the self-reported adversity measure) are included for comparison.