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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Am J Psychiatry. 2018 Mar 2;175(6):545–554. doi: 10.1176/appi.ajp.2017.17060621

Table 2.

Tests for gene-by-environment interaction between adversity and genetic variants predicting major depression.

Test Model 1: Interaction Model 2: Covariate
OR 95%CI P-value R2 OR 95%CI P-value
chr1:rs7526682_G 1.29 1.17–1.43 1.94×10−7 0.0024 1.20 1.10–1.31 2.50×10−5
Adversity 2.21 1.99–2.46 2.22×10−48 0.0316 2.03 1.85–2.23 5.21×10−51
adversity:rs7526682 0.73 0.60–0.89 0.0016 0.0013 – – –
chr1:rs11577545_T 1.28 1.17–1.39 1.48×10−8 0.0018 1.14 1.06–1.23 0.0003
Adversity 2.41 2.15–2.71 4.38×10−49 0.0311 2.02 1.84–2.22 3.11×10−50
adversity:rs11577545 0.67 0.57–0.79 9.31×10−7 0.0032 – – –
chr8:rs950893_G 0.80 0.74–0.86 5.05×10−9 0.0029 0.86 0.81–0.92 3.28×10−6
Adversity 1.74 1.54–1.97 6.47×10−19 0.0311 2.02 1.84–2.22 3.04×10−50
adversity:rs950893 1.31 1.13–1.52 0.0003 0.0018 – – –
chr10:rs12415800_A 1.17 1.10–1.26 2.77×10−6 0.0035 1.16 1.10–1.23 2.87×10−7
Adversity 2.10 1.81–2.45 2.76×10−22 0.0315 2.03 1.85–2.23 1.00×10−50
adversity:rs12415800 0.96 0.84–1.10 0.5630 <0.0001 – – –
chr10:rs35936514_T 0.85 0.79–0.92 3.61×10−5 0.0037 0.84 0.79–0.90 1.61×10−7
Adversity 2.09 1.85–2.36 2.80×10−32 0.0315 2.03 1.85–2.23 7.43×10−51
adversity:rs35936514 0.95 0.82–1.10 0.5010 <0.0001 – – –

This table shows the odds ratio (OR), 95% confidence interval of OR, and P-value of the minor allele of each single nucleotide polymorphism (SNP) association with major depression in the full cohort in logistic regression, with an interaction term between SNP and self-reported adversity (adversity:SNP) term included in Model 1, and without it in Model 2. All analyses performed using 10 principal components as covariates, bold font indicates significant genetic effect (P < 5.0×10−8) or gene by environment interaction (P < 0.005).