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. Author manuscript; available in PMC: 2019 Jul 16.
Published in final edited form as: Behav Brain Res. 2018 Mar 28;347:368–376. doi: 10.1016/j.bbr.2018.03.043

Figure 8.

Figure 8

Proposed mechanistic events associated with changes in the xCT expression in the NAc and HIP for the attenuation of HYD-seeking behavior with CEF treatment. (1) HYD reinstatement was associated with reduction in the xCT expression in the NAc and HIP. This could be due to the effect of repeated exposure to HYD during the conditioning phase and HYD priming during the reinstatement phase. (2) The reduction in xCT expression may decrease the glutamatergic tone on mGluR2/3 and loss of the inhibitory mechanism on glutamate release. (3) High level of extracellular glutamate facilitates HYD reinstatement. (4) CEF treatment during the extinction phase increased xCT expression in the NAc and HIP, which could restore the glutamatergic tone on mGluR2/3. Restoring the inhibitory mechanism on glutamate release through mGluR2/3 could prevent high levels of extracellular glutamate and attenuate HYD reinstatement.