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. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: J Immunol. 2018 Apr 27;200(12):4012–4023. doi: 10.4049/jimmunol.1800112

Figure 6. Talin modulates multiple aspects of the Treg cell transcriptome.

Figure 6

(A) RNA-seq analysis of mRNA expression in sorted Treg cells isolated from Tlnwt/wtFoxp3Cre/wt (n=4) or Tlnfl/flFoxp3Cre/wt mice (n=3), expressed as log2 normalized counts. Individual points represent genes upregulated (red), downregulated (blue), or not significantly changed (black) in talin-deficient Treg cells (adjusted P-value < 0.05) compared to controls. (B–F) Heatmaps showing fold-change of differentially expressed genes within selected significantly enriched GO categories.

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