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. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: J Immunol. 2018 May 2;200(12):4170–4179. doi: 10.4049/jimmunol.1701465

Figure 4. MiR-155 expression in donor T cells is important for modulating their exhaustion status in end target organs.

Figure 4

B6D2F1 mice were lethally irradiated with 1100cGy and transplanted with 10×106 B6 WT T cell depleted bone marrow cells and either 20×106 GFP+ B6 WT or GPF+ miR-155−/−. On day 10, a cohort of mice was euthanized and liver as well as colonic lamina propria were harvested for flow cytometric analysis. N= 5-7 mice in each group for each time point. P values <0.05 were considered significant using Student’s t-test with Holm-Sidak method. For all panels, NS p>0.05, * p<0.05, ** p<0.01, and *** p<0.001. Data expressed as mean ± SD. (A) Percentage of CTLA-4+, PD-1+, Tim3+, or Lag3+ donor CD8+ and CD4+ T cells on day 10 post-transplant from colonic lamina propria. (B) Percentage of CTLA-4+, PD-1+, Tim3+, or Lag3+ donor CD8+ and CD4+ T cells on day 10 post-transplant from liver.