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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Clin Immunol. 2018 Mar 21;192:6–13. doi: 10.1016/j.clim.2018.03.010

Figure 4.

Figure 4

Local reaction after first (V1), third (V3) and sixth (V6) inoculations. Figure 4A: All patients. The local reaction to the last inoculation of the PVS was significantly greater than the first (V6: 104.3±10.7mm vs V1: 48.4±11.4mm, p=0.001). Figure 4B: By dosing group. Both high dose and low dose groups showed significant increase at V6 vs V1 (low dose: 87.8±15.8 vs. 32.9±14.8mm, p=0.02; high dose: 127.3±9.2mm vs. 62.0±16.2mm, p=0.008). The high dose group showed consistently larger local reactions than the low dose group, with the difference being significant at V3 (V1: p=0.2, V3: p=0.02; V6: p=0.07). Figure 4C: By study arm. All groups showed an increase at V6 vs V1, but only the EE′ group showed a statistically significant increase (EE: p=0.07, EE′: p=0.002, E′E: p=0.14). *=p<0.05.