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. 2018 May 30;9:391. doi: 10.3389/fneur.2018.00391

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Copyright © 2018 Schneider, Kemmling, Schroeder, Pantel, Glatzel, Schoen, Mohme, Fiehler and Gellißen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of perfusion calculation from caudal to cranial (1–4). (A) Example of the 1 mm MNI brain that served as a template for co-registration of the patient's contrast-enhanced T1-weighted images and the CT perfusion map. (B) Display of the cerebral blood flow (CBF) map (see color scale on the upper right; light yellow also corresponds to CBF values ≥120 ml/100 g/min due to better visualization). Cerebral blood volume (CBV), mean transit time (MTT), and time to peak (TTP) maps are not depicted. (C) Cumulative brain metastases frequency map (see color scale on the lower right; light blue also corresponds to ≥8 brain metastases due to better visualization). (D) Overlay of the metastases sum map, the perfusion map, and the MNI brain. CBF, CBV, MTT, and TTP values were extracted for each voxel-group with and without a BM.