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. 2018 Jun 6;8:8676. doi: 10.1038/s41598-018-26999-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of lobohedleolide on the transcriptional factor activity on COX-2 promoter. (a) Schematic diagrams of the deletion of COX-2 promoter constructs. (b) Effect of lobohedleolide on the deletion constructs of COX-2 promoter. Ava5 cells were cotransfected with 0.2 μg of pCMV-Rellina-Luc and pCOX-2-Luc, pCOX-2(ΔNF-κB)-Luc, or pCOX-2(ΔNF-κB/C/EBP)-Luc for 6 h. The transfected cells were treated with DMSO or lobohedleolide at 20 and 40 μM for 3 days. Cell lysates were subjected to luciferase activity assay. Data are presented as mean ± SD of at least three independent experiments, with each measurement carried out in triplicate. Asterisks indicate significant difference between lobohedleolide- and DMSO-treated Ava5 cells. *P < 0.05; **P < 0.01.