Table 3.
Univariate and multivariate logistics regression analysis to assess factors associated with the response to terlipressin treatment
| Variables |
Univariate analysis |
Multivariate analysis |
||
| OR (95%CI) | P value | OR (95%CI) | P value | |
| Age | 1.024 (0.975-1.075) | 0.344 | ||
| Gender | 0.35 (0.090-1.357) | 0.129 | ||
| Grouping (DC/ACLF) | 0.282 (0.087-0.913) | 0.035 | 0.282 (0.087-0.913) | 0.035 |
| Baseline serum creatinine | 1.074 (0.417-2.77) | 0.882 | ||
| Peak serum creatinine | 0.499 (0.268-0.930) | 0.029 | ||
| Cirrhosis | 1.50 (0.513-4.385) | 0.459 | ||
| HE | 0.318 (0.103-0.981) | 0.046 | - | 0.148 |
| GI bleeding | 1.091 (0.262-4.537) | 0.905 | ||
| Ascites | 0.735 (0.044-12.330) | 0.831 | ||
| SBP | 0.452 (0.125-1.633) | 0.226 | ||
| Pulmonary infection | 0.970 (0.324-2.904) | 0.956 | ||
| ALT | 0.997 (0.993-1.001) | 0.153 | ||
| AST | 0.997 (0.993-1.002) | 0.095 | ||
| Serum albumin | 0.986 (0.895-1.1087) | 0.782 | ||
| Serumbilirubin | 0.956 (0.917-0.996) | 0.032 | ||
| Serum sodium | 1.071 (0.986-1.163) | 0.103 | ||
| INR | 0.462 (0.260-0.823) | 0.009 | ||
| Leukocyte count | 0.903 (0.816-0.999) | 0.048 | - | 0.180 |
| MAP | 0.998 (0.937-1.062) | 0.944 | ||
| Child-Pugh score | 0.809 (0.608-1.076) | 0.146 | ||
| MELD | 0.921 (0.870-0.975) | 0.004 | ||
| Treatment time | 1.020 (0.978-1.065) | 0.352 | ||
DC: Decompensated chirrhosis; ACLF: Acute-on-chronic liver failure; HE: Hepatic encephalopathy; GI: Gastrointestinal; SBP: Spontaneous bacterial peritonitis; ALT: Alanine amino transaminases; AST: Aspartate transaminases; INR: International normalized ratio; MAP: Mean arterial pressure; MELD: Model of end-stage liver disease score.