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. 2018 Jun 6;9:2189. doi: 10.1038/s41467-018-04559-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The modular organization of the developmental splicing program is pan-neuronal. a The splicing profile of module exons in different neuronal subtypes. Exons are shown in the same order as in the cortex reference. DIV: days in vitro. For differentiation of glutamatergic neurons from ESCs, cells on DIV 0 are enriched in radial glia committed to the neuronal fate, which becomes post-mitotic on DIV 1. b Quantification of developmental splicing switches among module exons in different neuronal subtypes. In each dataset, M1+/M1− and M2+/M2− core module exons also showing differential splicing (|ΔΨ| ≥ 0.2, Benjamini FDR ≤0.05) in each pairwise comparison were counted. The number of exons showing increased inclusion at later time points is shown above the diagonal (top right), and the numbers of exons showing decreased inclusion is shown below the diagonal (bottom left)