Fig. 1.
PTL reduces cell viability and migration of primary pulmonary fibroblasts (PPF) and HFL1 cells (a) The PPF isolated from NaCl-treated mice were treated with indicated dosages of PTL for 24 h (IC50 = 10.68 μM). PTL reduced the cell viability in a dose-dependent manner. b, c The PPF isolated from NaCl-treated mice were incubated in a medium containing PTL (0, 2.5, 5, 10, and 20 μM) for 24 h. Results showed that cell viability and migration were inhibited after incubation in different groups for 24 h. d The PPF isolated from BLM-treated mice were treated with indicated dosages of PTL for 24 h (IC50 = 26.01 μM). PTL reduced the cell viability in a dose-dependent manner. e, f The PPF isolated from BLM-treated mice were incubated in a medium containing PTL (0, 2.5, 5, 10, and 20 μM) for 24 h. g The HFL1 cells were treated with indicated dosages of PTL for 24 h (IC50 = 13.66 μM). PTL reduced the cell viability in a dose-dependent manner. h, i The HFL1 cells were incubated in a medium containing PTL (0, 2.5, 5, 10, and 20 μM) for 24 h