Table 2.
Association of the top seven miRNA SNPs with p < 5 × 10−6 and breast cancer risk
| SNP | Chromosome:positiona | Effect/other allele | EAF | OR (95% CI) | p b | FDR pc | INFO (r2) |
|---|---|---|---|---|---|---|---|
| rs142882938 | 17:79010031 | C/CT | 0.06 | 1.45 (1.24–1.70) | 5.9 × 10–7 | 0.03 | 0.97 |
| rs4969239d | 17:79010544 | G/A | 0.08 | 1.35 (1.20–1.52) | 1.4 × 10–6 | 0.06 | – |
| rs28585511 | 17:79010609 | T/A | 0.06 | 1.45 (1.26–1.66) | 5.8 × 10–7 | 0.03 | 0.98 |
| rs4969351 | 17:79011141 | A/G | 0.08 | 1.35 (1.20–1.52) | 3.4 × 10–6 | 0.11 | 0.99 |
| rs9913477 | 17:79015698 | G/A | 0.06 | 1.44 (1.26–1.65) | 3.2 × 10–7 | 0.03 | 0.99 |
| rs7502931 | 17:79018677 | G/A | 0.06 | 1.44 (1.26–1.65) | 3.4 × 10–7 | 0.03 | 0.99 |
| rs4969366d | 17:79026572 | G/A | 0.05 | 1.45 (1.24–1.70) | 1.5 × 10–6 | 0.06 | – |
The seven single nucleotide polymorphisms (SNPs) are intronic to BAIAP2 and located in the primary transcript of miR-3065
Significant FDR results are shown in bold
CI, confidence interval; EAF, effect allele frequency; FDR, false discovery rate; INFO, imputation quality score; OR, odds ratio
aHuman Genome GRCh37/hg19 assembly, NT_010783.15
bAdditive genetic models were adjusted for age group (by ~ 10-year intervals), study site, geographic region of residence, DNA source, and ancestry (PCs 5, 6, and 8 associated with cancer trait, p < 0.1). Sample size: 3663 cases and 4687 controls
cAdjustment for multiple comparisons using the FDR
dGenotyped SNPs, with the other SNPs having been imputed to 1000 Genome Project data