Table 3. A list of components that present high spearman correlation in the MCPM regarding panobinostat.
| Drug type | Component | Metabolic pathway | Correlation / P value |
|---|---|---|---|
| Panobinostat | ATP6V0E1 | Purine | 0.3775625 p=2.262852e-17 |
| Panobinostat | UPP1 | Pyrimidine | 0.3762676 p=2.963006e-17 |
| Panobinostat | 3,4-Dihydroxymandelate | Tyrosine | 0.3723126 p=3.021123e-17 |
| Panobinostat | PAPSS2 | Purine | 0.3375621 p=5.454525e-14 |
| Panobinostat | NT5E | Purine, pyrimidine | 0.3049326 p=1.431208e-11 |
These components and reactions are from purine, pyrimidine and tyrosine pathways