Table 6.
Top 10 ranked genes of each method
| MGOGP | Endeavor | GeneFriends | PINTA | ToppGene | ToppNet | |
|---|---|---|---|---|---|---|
| Top 10 gene | CCNB1IP1 CCNE2 NEK1 NRP1 CDC25C VIM PTEN VEGFB MCM2 PTGS2 |
SNRPF BUB3 MSH2 SSBP1 RFC4 EZH2 CENPF BLMH KIF20B BAZ1A |
LURAP1L PVRL2 CYFIP1 FAM120A IL13RA1 MYO1B BCL9L NQO1 RIN2 SDC4 |
MGP EEF1A1 TPT1 RPS6 RPL3 RPS27 ACTB SCGB2A2 RPL11 PIP |
RAD51 APEX1 SIRT2 NOC2L NEDD1 TERT EPN3 PPARGC1A NBN ATR |
APP ELAVL1 NTRK1 RPA1 XPO1 EED CUL3 BARD1 HSP90AA1 NXF1 |
| Known disease genes fall in the top 10 gene | PTEN VEGFB MCM2 |
MSH2 EZH2 |
NQO1 | SCGB2A2 PIP |
RAD5 TERT NBN ATR |
BARD1 |
In Table 6, each method is run with default parameter settings and use same training genes. Top 10 gene means the top 10 genes prioritized by each method and Known disease genes fall in the top 10 gene means genes supplied for training each method falls in the top 10 genes. Detail statistic results are shown in Fig. 7