Table 3.
Association of quantitative background parencymal uptake (BPU) (per 1 unit BPU) with breast cancer
| OR (95% CI), adjusted for BMI | OR (95% CI), adjusted for BMI and PD | OR (95% CI), adjusted for BMI and postmenopausal hormones | |
|---|---|---|---|
| Overall | |||
| Operator 1 | 3.70 (1.54–8.92) | 3.98 (1.58–10.05) | 3.85 (1.58–9.38) |
| p value | 0.0036 | 0.0034 | 0.0030 |
| AUC (95% CI) | 0.63 (0.56–0.71) | 0.66 (0.59–0.73) | 0.63 (0.56–0.70) |
| Operator 2 | 2.37 (1.19–4.70) | 2.35 (1.17–4.71) | 2.31 (1.17–4.55) |
| p value | 0.0136 | 0.0163 | 0.0154 |
| AUC (95% CI) | 0.58 (0.51–0.66) | 0.61 (0.54–0.69) | 0.61 (0.54–0.69) |
| Postmenopausal women (n = 187: 49 cases, 138 controls) | |||
| Operator 1 | 5.57 (1.62–19.08) | 8.39 (2.10–33.55) | 5.87 (1.69–20.36) |
| p value | 0.0063 | 0.0026 | 0.0053 |
| AUC (95% CI) | 0.65 (0.57–0.73) | 0.70 (0.62–0.78) | 0.65 (0.57–0.73) |
| Operator 2 | 2.91 (1.15–7.35) | 3.62 (1.34–9.79) | 2.99 (1.18–7.57) |
| p value | 0.0239 | 0.0113 | 0.0212 |
| AUC (95% CI) | 0.57 (0.48–0.65) | 0.66 (0.58–0.74) | 0.61 (0.53–0.69) |
| Premenopausal women (n = 51: 13 cases, 38 controls) | |||
| Operator 1 | 2.42 (0.73–8.04) | 2.09 (0.64–6.79) | NA |
| p value | 0.1492 | 0.2224 | |
| AUC (95% CI) | 0.57 (0.41–0.73) | 0.58 (0.42–0.73) | |
| Operator 2 | 1.70 (0.63–4.58) | 1.47 (0.54–3.98) | NA |
| p value | 0.2922 | 0.4468 | |
| AUC (95% CI) | 0.62 (0.47–0.78) | 0.61 (0.45–0.76) | |
AUC, area under the curve; BMI, body mass index; CI, confidence interval; NA, not applicable; OR, odds ratio; PD, percent density by Cumulus software