Table 5.
Pathways in common in all breast cancer subtypes and specific for each subtype as derived from the proposed network approach
| Common to all | Luminal A | Luminal B | HER2 | Basal |
|---|---|---|---|---|
| Assembly of RNA polymerase II complex | Cell cycle regulation by BTG family proteins | Antioxidant action of vitamin C | Actin cytoskeleton signaling | Aryl Hydrocarbon Receptor Signaling |
| Axonal guidance signaling | Chemokine signaling | Germ cell-sertoli cell junction signaling | Adrenergic signaling | eNOS signaling |
| Coagulation system | Chondroitin sulfate biosynthesis | HMGB1 signaling | Breast cancer regulation by Stathmin1 | Fatty acid oxidation I |
| Colorectal cancer metastasis signaling | chondroitin sulfate biosynthesis (late stages) | IL-6 signaling | cAMP-mediated signaling | Gluconeogenesis I |
| EIF2 signaling | Ephrin B signaling | Linolenate biosynthesis II (animals) | Cardiac hypertrophy signaling | Glycolysis I |
| Ethanol degradation II | Granulocyte adhesion and diapedesis | Antioxidant action of vitamin C | Caveolar-mediated endocytosis signaling | IL-1 signaling |
| Ethanol Degradation IV | Heparan sulfate biosynthesis | Germ cell-sertoli cell junction signaling | Corticotropin Releasing Hormone Signaling | Mitochondrial Dysfunction |
| Extrinsic prothrombin activation pathway | Heparan sulfate biosynthesis (late stages) | HMGB1_Signaling | CREB signaling in neurons | mTOR signaling |
| Fatty acid-oxidation | LXR/RXR activation | IL-6 signaling | DNA damage-induced 14–3–3 signaling | Phenylalanine Degradation IV (Mammalian, via Side Chain) |
| HIF1 signaling | Pancreatic adenocarcinoma signaling | Linolenate biosynthesis II (animals) | Endothelin-1 signaling | Phototransduction pathway |
| Histamine degradation | Pregnenolone biosynthesis | Gap junction signaling | PI3K/AKT signaling | |
| Noradrenaline and adrenaline degradation | Regulation of cellular mechanics by calpain protease | GDNF family ligand–receptor interactions | ||
| Oxidative ethanol degradation III | Semaphorin signaling in neurons | Glycine betaine degradation | ||
| Putrescine degradation III | Superoxide radicals degradation | Glycogen degradation II | ||
| Tryptophan degradation X (mammalian, via tryptamine) | Induction of apoptosis by HIV1 | |||
| Leptin signaling in obesity | ||||
| Macropinocytosis signaling | ||||
| NAD biosynthesis II (from tryptophan) | ||||
| Ovarian cancer signaling | ||||
| Relaxin signaling | ||||
| RhoGDI signaling | ||||
| Role of IL-17A in psoriasis | ||||
| Role of tissue factor in cancer | ||||
| Sperm motility | ||||
| Synaptic long term depression | ||||
| tRNA splicing | ||||
| Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
| TWEAK Signaling |
In italics pathways that are target of FDA-approved drugs for breast cancer are indicated