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. 2018 Jun 5;20:111. doi: 10.1186/s13075-018-1600-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Significantly changed metabolites in patients with hyperuricemia (HUA) and patients with gout. a Numbers of significant metabolites. b Heatmap of significantly changed metabolites. The color of each section corresponds to a concentration value of each metabolite calculated by the peak area normalization method (red, upregulated; blue, downregulated)