Table 2.
Summary of significantly changed metabolites in the HUA and gout group
| Metabolites | Changes in HUA (vs control) |
Changes in gout (vs control) |
Changes in gout (vs HUA) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Trend | r a | p b | Trend | r a | p b | Trend | r a | p b | |
| VLDL | ↑ | 0.71 | 0.00 | ↑ | 0.61 | 0.00 | ↑ | 0.61 | 0.00 |
| Isoleucine | ↑ | 0.86 | 0.00 | ↑ | 0.72 | 0.00 | – | – | – |
| Leucine | ↑ | 0.83 | 0.00 | ↑ | 0.71 | 0.00 | – | – | – |
| Lipid | ↑ | 0.68 | 0.00 | ↑ | 0.72 | 0.00 | ↑ | 0.63 | 0.00 |
| Lactate | ↑ | 0.70 | 0.00 | – | – | – | – | – | – |
| Alanine | ↑ | 0.77 | 0.00 | – | – | – | – | – | – |
| Lysine | ↑ | 0.76 | 0.00 | – | – | – | – | – | – |
| Glutamine | – | – | – | ↑ | 0.60 | 0.00 | – | – | – |
| Methionine | – | – | – | ↑ | 0.67 | 0.00 | – | – | – |
| Acetone | ↑ | 0.64 | 0.00 | ↑ | 0.63 | 0.00 | ↑ | 0.65 | 0.00 |
| Glutamate | ↑ | 0.69 | 0.00 | – | – | – | – | – | – |
| Citrate | – | – | – | ↑ | 0.68 | 0.00 | ↑ | 0.65 | 0.00 |
| Aspartate | – | – | – | ↑ | 0.73 | 0.00 | ↑ | 0.63 | 0.00 |
| Creatinine | ↑ | 0.63 | 0.00 | ↑ | 0.65 | 0.00 | – | – | – |
| β-Glucose | ↑ | 0.65 | 0.00 | ↑ | 0.70 | 0.00 | ↑ | 0.65 | 0.00 |
| α-Glucose | ↑ | 0.63 | 0.00 | ↑ | 0.68 | 0.00 | ↑ | 0.66 | 0.00 |
| Threonine | ↑ | 0.65 | 0.00 | ↑ | 0.60 | 0.00 | – | – | – |
| Triglycerides | ↑ | 0.70 | 0.00 | ↑ | 0.61 | 0.00 | – | – | – |
| Unsaturated lipids | ↑ | 0.67 | 0.00 | ↑ | 0.63 | 0.00 | – | – | – |
| Tyrosine | ↑ | 0.75 | 0.00 | – | – | – | – | – | – |
| Phenylalanine | – | – | – | ↑ | 0.63 | 0.00 | – | – | – |
Increased levels are indicated by arrows (↑)
VLDL very low-density lipoprotein
aCorrelation coefficient (r) was obtained from the orthogonal partial least squares-discriminant analysis model
bThe p value was calculated using Student’s t test