. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: J Alzheimers Dis. 2018;62(2):745–756. doi: 10.3233/JAD-170834

Table 5.

Association results of the longitudinal regression models for Polygenic Risk Scored derived for Lambert hits


	CDR-SB (N=1,499)

	Beta^?	P
*PRStime**	0.146	0.029
*APOEtime**	0.045	0.041
*PRS+APOEtime**	0.054	9.51×10⁻⁰³

The model for longitudinal regression was adjusted for CDR baseline, follow-up time, sex, age, education, the first two principal components (PC1, PC2) and the interaction term CDR baseline* follow-up time. The beta and p values are the results for the interaction terms of PRS, APOE and PRS+APOE and time in the model. Abbreviations: PRS, Polygenetic Risk Score. APOE, Apolipoprotein E. P, p-value.

The effects of APOE genotype on AD risk are not additive. APOE is added to the model the scale of PRS is totally different to the scale without APOE, and therefore the effect size can not be compared directly.