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. Author manuscript; available in PMC: 2019 Feb 28.
Published in final edited form as: Chem Rev. 2018 Jan 11;118(4):1599–1663. doi: 10.1021/acs.chemrev.7b00504

Figure 13.

Figure 13

DNA G-quadruplex binding ligands. (A) Structure of DNA G-quadruplex. (B) Different DNA strand directions, antiparallel, mixed-type, and parallel, result in different G-quadruplex structures. (C) Structure of BSU1051 which targets human telomeric G-quadruplex. (D) Structure of TMPyP4 which targets the promoter region of c-Myc. (E) Structure of PDS which targets telomeric G-quadruplex and proto-oncogene tyrosine-protein kinase Src. (F) Structure of quarfloxin which targets the rDNA G-quadruplex and inhibits Pol I transcription.