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. Author manuscript; available in PMC: 2019 Feb 28.
Published in final edited form as: Chem Rev. 2018 Jan 11;118(4):1599–1663. doi: 10.1021/acs.chemrev.7b00504

Figure 16.

Figure 16

Lead optimization of a lead compound that targets the Drosha site of miR-96 to afford Targaprimir-96, a dimeric small molecule that targets the Drosha site and an adjacent 1 × 1 GG internal loop.