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Timeline detailing the emergences of FQR Shigella species. The dashed lines represent the first occurrences of the initial QRDR mutation in the FQR clone if known, as described by epidemiological or genomic data. The solid lines indicate the first reports of FQR Shigella species as well as the QRDR mutations that became incorporated into these clones by this designated time. The presumed order of occurrence for these mutations is from top to bottom.
