Table 2.
Observational studies examining outcomes after parathyroidectomy in patients on dialysis
| Study | Country | Sample Size, PTx/Medical Treatment | Mean Age, yr | Women, % | Dialysis Duration, mo | Mean Duration of Follow-Up, mo | Study Period | Mean Serum iPTH, pg/ml | Mortality Difference with PTx |
|---|---|---|---|---|---|---|---|---|---|
| Kestenbaum et al., 2004 (56) | United States | 4558/4558 | 47.6 | 57.5 | 40.2 | 36 | 1994–2001 | Not reported | Short-term ↑ death <90 d after PTx; long-term ↓ all-cause death 15% |
| Sharma et al., 2012 (57) | United States | 150/1044 | 42.0 | 53.0 | 86.4 | 43.2 | 1993–2009 | 1770.0 | ↓ All-cause death 37%, ↓ CV death 33% |
| Goldenstein et al., 2013 (58) | Brazil | 123/128 | 48.0 | 45.7 | 72.0 | 23 | 2005–2012 | 1455.1 | ↓ All-cause death 57% |
| Ivarsson et al., 2015 (59) | Sweden | 423/1234 | 55.8 | 50.4 | Not reported | 56.3 | 1991–2009 | Not reported | ↓ All-cause death 20% |
| Komaba et al., 2015 (51) | Japan | 4428/4428 | 59.2 | 44.3 | 150.5 | 12 | 2004–2005 | 382.5 | ↓ All-cause death 34%, ↓ CV death 41% |
A consistent association with improved survival was observed in the dialysis population across studies. PTx, parathyroidectomy; iPTH, intact parathyroid hormone level; CV, cardiovascular.