Table 1.
Selected Clinical Trials Targeting PDAC Stroma
| TARGET | STRATEGY | TRIAL |
|---|---|---|
| Hyaluronan | PEGylated hyaluronidase |
NCT02715804 NCT01959139 |
| Connective Tissue Growth Factor | Monoclonal Ab to CTGF (pro-fibrotic mediator) |
NCT02606136 NCT02210559 |
| Angiotensin | Angiotensin Inhibitor losartan via preventing PKC and EGF-ERK pathway activation | NCT01821729 |
| Angiogenesis | Hypoxia activated prodrug TH-302 | NCT01746979 |
| CXCR4 inhibitor | Combination of CXCR4 inhibition AND checkpoint inhibition | NCT02301130 |
| Vitamin D analogs | Vitamin D receptor activation decreases fibrosis |
NCT02930902 NCT02030860 |
| Focal Adhesion Kinase (FAK) inhibition | FAK implicated in cancer migration, proliferation and survival |
NCT02758587 NCT02428270 NCT025465310 |