Table I.
Microarray Analysis of Baicalein Treated Cancer Cells at 12 and 24 Hours
| Symbol | Fold Change |
p-value | Entrez Gene Name |
|---|---|---|---|
| 24 Hours | |||
| DDIT4 | 5.397 | 4.42E-14 | DNA-damage-inducible transcript 4 |
| INHBE | 3.958 | 4.92E-09 | inhibin, beta E |
| S100P | 3.134 | 1.98E-13 | S100 calcium binding protein P |
| CHAC1 | 3.077 | 2.54E-12 | ChaC, cation transport regulator homolog 1 (E. coli) |
| ASNS | 2.986 | 5.54E-15 | asparagine synthetase (glutamine-hydrolyzing) |
| SLC7A11 | 2.929 | 2.69E-14 | solute carrier family 7, member 11 |
| ECM2 | 2.909 | 1.33E-08 | extracellular matrix protein 2, female organ/adipocyte specific |
| CTH | 2.738 | 4.21E-11 | cystathionase (cystathionine gamma-lyase) |
| PCK2 | 2.618 | 1.43E-11 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
| IFI44L | 2.580 | 4.46E-08 | interferon-induced protein 44-like |
| XAF1 | 2.298 | 4.96E-08 | XIAP associated factor 1 |
| ANKRD1 | 2.298 | 5.87E-09 | ankyrin repeat domain 1 (cardiac muscle) |
| KIF21B | 2.278 | 7.28E-10 | kinesin family member 21B |
| SERPINB2 | 2.173 | 3.36E-07 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
| IL8 | 2.110 | 2.73E-08 | interleukin 8 |
| SLC1A4 | 2.098 | 3.19E-10 | solute carrier family 1, member 4 |
| RIMKLB | 2.095 | 1.71E-05 | ribosomal modification protein rimK-like family member B |
| HUS1 | 2.063 | 2.54E-07 | HUS1 checkpoint homolog (S. pombe) |
| C1ORF116 | 2.036 | 9.05E-10 | chromosome 1 open reading frame 116 |
| NT5DC4 | 2.026 | 3.55E-07 | 5'-nucleotidase domain containing 4 |
| IFI44 | 2.010 | 1.42E-06 | interferon-induced protein 44 |
| 12 Hours | |||
| DDIT4 | 3.222 | 3.38E-12 | DNA-damage-inducible transcript 4 |
AGS cells were treated with DMSO or baicalein at 20µM in triplicate for 12 or 24h. Total RNA was isolated and ultimately evaluated by microarray using the Affymetrix Human Genome U133 Plus 2.0 arrays. Significant differentially expressed genes were determined using Partek® software.