TABLE 1.
Examples of Precision Medicine Testing in Use Today
| Clinical Question: | Susceptibility | Screening | Diagnosis | Prognosis | Drug Response | Monitoring | |
|---|---|---|---|---|---|---|---|
| Cancer | Indication: | Breast Colon Sarcomas |
Cervical | Cancer of unknown primary Ovarian Cancer |
Breast Cancer | Imatinib (CML) Crizotinib (NSCL) |
Tumor recurrence or progression |
| Test: |
BRCA1, BRCA2 HNPCC TP53, PTEN |
HPV genotypes | Cancer Origin™ OVA1® |
Oncotype DX (21-gene assay) MammaPrint (70-gene assay) HER2/neu, ER, PR |
BCR-ABL EML4-ALK |
CTCs | |
| Cardiovascular Disease | Indication: | CAD | Familial Hypercholesterolemia |
1. Long QT Syndrome 2. ACS 3. CAD |
ACS | 1. Clopidogrel 2. Statins 3. Warfarin |
Transplant rejection |
| Test: | 9p21 | APOB, LDLR, LDLRAP1, PCSK9 |
1. KVLQT1, HERG, SCN5A, ANKB, Mink, MiRP1, KCNJ2, CACNA1C, CAV3, SCN4- beta 2. TnI, BNP, CRP 3. CorusCAD® |
cTnI |
1. CYP2C19 2. SLCO1B1 3. CYP2C9 VKORC1 |
AlloMap® |
ACS = acute coronary syndromes; BNP = brain natriuretic peptide; CAD = coronary artery disease; CRP = C-reactive protein; CTCs = circulating tumor cells; ER = estrogen receptor; HPV = human papillomavirus; LQTS = long QT syndrome; PR = progesterone receptor; TnI = troponin I.