Table 3.

Univariate and multivariable analysis of overall survival in lung adenocarcinoma from TCGA dataset

Variable	Univariate analysis			Multivariable analysis
	HR	95% CI	P a	HR	95% CI	P a
Gender
Female	Reference			Reference
Male	0.89	0.61‐1.29	.5578	0.79	0.53‐1.16	.2280
Age
>65 years	Reference			Reference
≤65 years	0.84	0.58‐1.22	.3720	0.76	0.51‐1.13	.1759
Smoking status
Never smoker	Reference			Reference
Former smoker	0.97	0.60‐1.63	.8969	1.45	0.86‐2.53	.1640
Current smoker	0.69	0.37‐1.28	.2342	0.76	0.40‐1.44	.3966
Stage
I	Reference			Reference
II	2.64	1.63‐4.26	<.0001	3.07	1.86‐5.07	<0.0001
III	4.42	2.74‐7.11	<.0001	4.66	2.87‐7.56	<0.0001
IV	3.29	1.54‐6.40	.0033	4.14	1.89‐8.31	0.0001
eIF2βmRNA expression
Low	Reference			Reference
High	1.96	1.07‐2.36	.0225	1.61	1.06‐2.41	.0255

^a P‐values were calculated by likelihood ratio test.