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Alendronate (ALN) treatment down‐regulated the expressions of Atrogin‐1 and SIRT3 in the soleus muscles of denervated mice. Alendronate (0.5 and 1 mg/kg) or vehicle was provided 4 weeks in mice, and mice were kept administration of ALN until 7 days after sham operation or sciatic nerve resection from right hind limb. The representative immunohistochemical images for the expressions of Atrogin‐1 and SIRT3 in the soleus muscles isolated from each group were shown (n = 4 of each group).
