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. 2018 May 8;19(7):609–621. doi: 10.1080/15384047.2018.1449613

Figure 7.

Figure 7.

A-macB has efficient antitumor activity in vivo without inducing significant cytotoxicity. (A) A-macB and cisplatin inhibited H1299 xenograft growth. (B) Growth curves showed that tumor volume was significantly smaller in the A-macB- and cisplatin-treated groups than in the vehicle control-treated group. (C) Xenograft tissue weight was substantially lower in the A-macB- and cisplatin-treated groups than in the vehicle control-treated group. (D) Mouse weight did not decline in any of the three groups. (E) No significant tissue injury occurred after A-macB or cisplatin administration compared with vehicle injection, as shown by H&E staining. (F) Histochemical analyses of the tumors. Sections of paraffin-embedded tumor tissue from each group of H1299 xenograft mice were stained with H&E (upper panel). Ki67 (middle panel) and cleaved caspase 3 (lower panel) was examined by IHC. (G) TUNEL assays confirmed that apoptosis was induced by A-macB or cisplatin. Data are presented as the mean ± SD (*p < 0.05, **p < 0.01, ***p < 0.001). (DDP: cisplatin, Fluo-12-dUTP: fluorescein-12-dUTP).