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. 2018 May 10;10(6):1879–1894. doi: 10.1016/j.stemcr.2018.04.006

Figure 6.

Figure 6

Fluorescence Time Lapse of Dofetilide-Induced Arrhythmogenesis

(A) Three ROIs are highlighted: (1) region with no detected triggered activity, (2) region with EAD/TA that did not develop to subsequent arrhythmia, and (3) region with TA that deteriorated into stable arrhythmia. Black scale bar: 2 s. White scale bar: 5 mm. Color scale bar represents fluorescence intensity (corresponding to voltage changes).

(B–K) Fluorescence time-lapse snapshots describing dofetilide-induced arrhythmogenesis. Note that following propagation of the first activation wave-front (B–C) and EAD/TA developed that failed to propagate and did not induce a stable arrhythmia (D). In contrast, following the second activation wave (E–F), a TA developed (G) that caused "figure-of-eight" reentry (H), unidirectional conduction block and eventually the development of a stablespiral wave (I–K).

See also Video S6. Dofetilide-Induced Arrhythmogenesis #1, Related to Figures 6 and 7 and Videos S7 and S8, Video S7. Dofetilide-Induced Non-propagating EADs, Related to Figures 6 and 7 and Videos S6, S8, and S9, Video S8. Dofetilide-Induced Propagating TA, Related to Figures 6 and 7 and Videos S6, S7, and S9, Video S9. Dofetilide-Induced Arrhythmogenesis #2, Related to Figures 6 and 7 and Videos S6–S8.