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. 2018 May 23;109(6):1743–1752. doi: 10.1111/cas.13613

Figure 2.

Figure 2

Schematic of chromosomal translocations present in low‐grade endometrial stromal sarcoma (LG‐ESS) (A) and high‐grade endometrial stromal sarcoma (HG‐ESS) (B). A, The most common translocation involves the short arm of chromosome 7 and long arm of chromosome 17(7;17) (p15;q21), leading to fusion of 2 zinc finger genes, JAZF1 and SUZ12, and production of JAZF1/SUZ12 gene fusion protein. B, Schematic of t(10;17) (q22;p13) chromosomal translocation present in HG‐ESS results in the fusion of the YWHAE and NUTM genes, leading to production of YWHAE/NUTM gene fusion proteins, which contributes to oncoprotein