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. 2018 Jan 29;9(3):570–584. doi: 10.1002/jcsm.12288

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© 2018 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Promyogenic role of XBP1 in myoblast differentiation (MD). (A–D) The expression of MyHC, myoG, and phospho‐AKT in XBP1‐dificent cells is detected by western bot and quantified. (E) Diagram illustrates timeline of experiment. (F) Phase contrast photomicroscopy revealed differentiated morphology in XBP1‐deficient myoblasts compared with ordinary myoblasts. The arrows indicate the fusion of myoblasts. Random views of three independent experiments at a magnification of ×100 were shown, scale bars = 200 μm.