Table 3.
Neisseria meningitidis Carriage Prevalence Among University Students 18–24 Years Old Before and After MenB-4C and MenACWY Vaccination.61
| Positive Isolatesa |
||||
|---|---|---|---|---|
| Vaccine group | MenB-4C% (n)b | MenACWY% (n) | Control% (n) | Carriage Rate Reduction, % (95% CI) |
| Baseline | N = 976 | N = 984 | N = 986 | |
| A, B, C, W, Y | 33 (326) | 34 (334) | 31 (303) | N/A |
| A | 0 | 0 | 0 | N/A |
| B | 9 (92) | 10 (100) | 9 (86) | N/A |
| C | 0 (3) | 0 (3) | 0 (3) | N/A |
| W | 2 (20) | 2 (20) | 1 (10) | N/A |
| Y | 7 (70) | 7 (67) | 7 (68) | N/A |
| Disease-associated capsular B | N = 974 | N = 984 | ||
| Baseline | 8 (78) | 7 (72) | N/A | |
| 1 month postvaccination 2 | 9 (87) | 8 (75) | 18.2 (–73.3–19.4) | |
| Serogroup A, C, W, or Y (combined) | N = 981 | N = 984 | ||
| Baseline | 6 (58) | 5 (49) | N/A | |
| 1 month postvaccination 2 | 6 (57) | 6 (58) | 10.5 (–34.2–40.3) | |
| >2 months postvaccination 1 | N = 3520 | N = 3504 | ||
| Capsular groups CWY | 9 (333) | 11 (388) | 27.1 (6.9–42.9) | |
| Capsular group Y | 7 (261) | 9 (325) | 26.5 (4.1–43.7) | |
| >3 months postvaccination 2 | N = 2489 | N = 2576 | ||
| N. meningitidis | 32 (797) | 34 (885) | 18.2 (3.4–30.8) | |
| Capsular group B | 9 (233) | 10 (262) | 15.6 (–11.0–35.9) | |
| Disease-associated capsular group B | 9 (214) | 9 (237) | 12.6 (–15.9–34.1) | |
| Capsular groups B, C, W, Y | 18 (449) | 21 (539) | 26.6 (10.5–39.9) | |
| Capsular groups C, W, Y | 9 (216) | 11 (277) | 29.6 (8.1–46.0) | |
| Capsular group Y | 7 (178) | 9 (228) | 25.1 (–0.2–44.0) | |
N/A = not applicable.
a
N. meningitidis-positive samples were identified via culture and biochemical confirmation; isolates were also characterized by genogroups, serogroups, and sequence types. Non-serogroupable isolates were evaluated by PCR (reported as combined or individual capsular groups).
b
Capsular group B isolate typing was based on multilocus sequence typing.