Figure 5.

Schematic rapresentation of PCL–PIP NPs formulation by nanoemulsion. The organic phase (red), non-miscible to water and containing the PCL–PIP prodrug, is poured in the aqueous solution containing PVA. The two solvents are then emulsified by sonication forming an oil in water (o/w) emulsion. The hydrophobic PCL–PIP locates in the organic droplets which are stabilized by PVA to avoid coalescence. The NPs suspension is stirred to allow solvent evaporation. Eventually, monodisperse NPs were formed devoid of PIP crystals.