Table 5.
HLA-C and KIR Genotype Paired Frequencies in Southampton AMD and Control Groups
| HLA+ KIR Genotypes |
AMD Group n = 104 (%) |
Control Group n = 93 (%) |
P* | Pc† | OR‡ | 95% CI |
|---|---|---|---|---|---|---|
| C1 group + AA | 31 (29.8) | 23 (24.7) | 0.42 | 2.52 | 1.29 | 0.68–2.43 |
| Cw*07 + AA | 25 (24.0) | 8 (8.6) | 0.003§ | 0.018§ | 3.36 | 1.43–7.89 |
| Cw*0701 + AA | 17 (16.3) | 4 (4.3) | 0.006§ | 0.036§ | 4.35 | 1.41–13.44 |
| C1 group + AB/BB | 67 (64.4) | 70 (75.3) | 0.09 | 0.54 | 0.59 | 0.32–1.10 |
| Cw*07 + AB/BB | 38 (36.5) | 38 (40.9) | 0.54 | 3.24 | 0.83 | 0.47–1.48 |
| Cw*0701 + AB/BB | 26 (25.0) | 21 (22.6) | 0.69 | 4.14 | 1.14 | 0.59–2.21 |
Two-sided probabilities using χ2 test.
Pc indicates probabilities after application of Bonferroni correction factor (n = 6).
OR, using the approximation of Woolf.
Significant values.