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. Author manuscript; available in PMC: 2018 Jun 6.
Published in final edited form as: Nat Genet. 2017 Oct 30;49(12):1752–1757. doi: 10.1038/ng.3985

Table 2. Plausible target genes with drugs in development for indications other than allergic diseases, for which the effect on gene expression of the allergy protective allele and the existing drug matched.

Plausible target gene Effect of allergy protective allele on gene expression Drug Action Drug Status Drug Name Originator Company Active Indications
CD86 Increased Agonist Discovery BR-02001 Boryung_Pharm_Co_Ltd Autoimmune_disease
CCR7 Decreased Antagonist Discovery anti-CCR7_chimeric_IgG1_antibodies North_Coast_Biologics_LLC Unidentified_indication
CCR7 Decreased Antagonist Discovery anti-CCR7_monoclonal_antibody Pepscan_Systems_BV Cancer
CCR7 Decreased Antagonist Discovery CCR7-targeting_antibody Abilita_Bio_Inc Metastatic_breast_cancer
CCR7 Decreased Antagonist NA chemokine_antagonists Neurocrine_Biosciences_Inc NA
CCR7 Decreased Antagonist NA chemokine_receptor_inhibitors Sosei_Group_Corp NA
F11R Decreased Antagonist Discovery F11R_inhibitors Provid_Pharmaceuticals_Inc Cardiovascular_disease
F11R Decreased Antagonist Discovery F-50073 Pierre_Fabre_SA Cancer
PHF5A Decreased Antagonist Discovery PHF5A_inhibitors Fred_Hutchinson_Cancer_Research_Center Glioblastoma
RGS14 Decreased Antagonist NA regulator_of_G-protein_signaling_14_inhibitor University_of_Malaga Memory loss
TARS2 Decreased Antagonist Discovery borrelidin Scripps_Research_Institute Infectious_disease