Table 1. Family-based heritability estimates not accounting for shared environmental effects calculated by Falconer’s method and regression coefficients derived from different relative pairs.
Disease | h2PO (SE) | h2SIB (SE) | h2PSIB (SE) | bAPO (SE) | bASIB (SE) | bPAR (SE) |
---|---|---|---|---|---|---|
Heart Disease | 0.368 (0.005) | 0.557 (0.018) | 0.514 (0.010) | 0.114 (0.026) | 0.145 (0.108) | 0.151 (0.003) |
Stroke | 0.162 (0.010) | 0.305 (0.044) | 0.260 (0.017) | -0.057 (0.054) | - | 0.038 (0.004) |
Bronchitis | 0.420 (0.009) | 0.501 (0.034) | 0.567 (0.017) | 0.169 (0.039) | 0.338 (0.138) | 0.108 (0.005) |
Hypertension | 0.366 (0.009) | 0.691 (0.010) | 0.477 (0.008) | 0.035 (0.021) | 0.190 (0.056) | 0.203 (0.002) |
Diabetes | 0.474 (0.007) | 0.692 (0.019) | 0.485 (0.012) | 0.067 (0.037) | 0.185 (0.098) | 0.109 (0.004) |
Alzheimer’s | 0.238 (0.061) | - | 0.349 (0.036) | - | - | 0.060 (0.005) |
Parkinson’s | 0.247 (0.038) | - | 0.214 (0.053) | - | - | 0.028 (0.013) |
Depression | 0.491 (0.007) | 0.443 (0.019) | 0.642 (0.013) | 0.250 (0.036) | 0.184 (0.083) | 0.162 (0.005) |
Lung cancer | 0.117 (0.038) | - | 0.314 (0.025) | - | - | 0.119 (0.005) |
Bowel cancer | 0.260 (0.017) | 0.387 (0.057) | 0.300 (0.023) | 0.171 (0.120) | - | 0.032 (0.005) |
Prostate cancer | 0.361 (0.022)¥ | 0.707 (0.062)¥ | 0.321 (0.036) ¥ | -0.053 (0.183) | - | - |
Breast cancer | 0.287 (0.014)Ψ | 0.393 (0.039)Ψ | 0.301 (0.025)Ψ | 0.144 (0.070) | - | - |
h2PO: heritability estimates using data of parents and offspring; (SE): Standard errors between brackets; h2SIB: heritability estimates using data of siblings; h2PSIB: heritability estimates using data of parents and siblings of participants; bAPO: regression coefficient of parents on adopted offspring; bASIB: regression coefficient of adoptive siblings; bPAR regression coefficient of parents of participants (partners); -: Effect was not estimated as there was less than one pair with both members affected
Only male-male pairs
Only female-female pairs.