Table 1. Family-based heritability estimates not accounting for shared environmental effects calculated by Falconer’s method and regression coefficients derived from different relative pairs.

Disease	h2PO (SE)	h2SIB (SE)	h2PSIB (SE)	bAPO (SE)	bASIB (SE)	bPAR (SE)
Heart Disease	0.368 (0.005)	0.557 (0.018)	0.514 (0.010)	0.114 (0.026)	0.145 (0.108)	0.151 (0.003)
Stroke	0.162 (0.010)	0.305 (0.044)	0.260 (0.017)	-0.057 (0.054)	-	0.038 (0.004)
Bronchitis	0.420 (0.009)	0.501 (0.034)	0.567 (0.017)	0.169 (0.039)	0.338 (0.138)	0.108 (0.005)
Hypertension	0.366 (0.009)	0.691 (0.010)	0.477 (0.008)	0.035 (0.021)	0.190 (0.056)	0.203 (0.002)
Diabetes	0.474 (0.007)	0.692 (0.019)	0.485 (0.012)	0.067 (0.037)	0.185 (0.098)	0.109 (0.004)
Alzheimer’s	0.238 (0.061)	-	0.349 (0.036)	-	-	0.060 (0.005)
Parkinson’s	0.247 (0.038)	-	0.214 (0.053)	-	-	0.028 (0.013)
Depression	0.491 (0.007)	0.443 (0.019)	0.642 (0.013)	0.250 (0.036)	0.184 (0.083)	0.162 (0.005)
Lung cancer	0.117 (0.038)	-	0.314 (0.025)	-	-	0.119 (0.005)
Bowel cancer	0.260 (0.017)	0.387 (0.057)	0.300 (0.023)	0.171 (0.120)	-	0.032 (0.005)
Prostate cancer	0.361 (0.022)¥	0.707 (0.062)¥	0.321 (0.036) ¥	-0.053 (0.183)	-	-
Breast cancer	0.287 (0.014)Ψ	0.393 (0.039)Ψ	0.301 (0.025)Ψ	0.144 (0.070)	-	-

h²_PO: heritability estimates using data of parents and offspring; (SE): Standard errors between brackets; h²_SIB: heritability estimates using data of siblings; h²_PSIB: heritability estimates using data of parents and siblings of participants; b_APO: regression coefficient of parents on adopted offspring; b_ASIB: regression coefficient of adoptive siblings; b_PAR regression coefficient of parents of participants (partners); -: Effect was not estimated as there was less than one pair with both members affected

^¥Only male-male pairs

^ΨOnly female-female pairs.