Table 2. Genetic and environmental effects estimated using the parsimonious reduced SEM model.
| Disease | Model | A (CI±0.95) | C (CI±0.95) | S (CI±0.95) | P (CI±0.95) | E (CI±0.95) |
|---|---|---|---|---|---|---|
| Heart Disease | ACSPE | 0.27 (0.24-0.27) | 0.08 (0.07-0.12) | 0.08 (0.07-0.08) | 0.06 (0.06-0.07) | 0.51 (0.49-0.57) |
| Stroke | APE | 0.23 (0.21-0.25) | - | - | 0.04 (0.03-0.04) | 0.73 (0.71-0.76) |
| Bronchitis | ACE | 0.29 (0.25-0.33) | 0.10 (0.10-0.11) | - | - | 0.61 (0.60-0.64) |
| Hypertension | ACSPE | 0.28 (0.28-0.29) | 0.06 (0.06-0.06) | 0.14 (0.14-0.14) | 0.13 (0.12-0.13) | 0.39 (0.38-0.39) |
| Diabetes | ASPE | 0.50 (0.49-0.52) | - | 0.11 (0.09-0.13) | 0.07 (0.06-0.08) | 0.32 (0.29-0.34) |
| Alzheimer’s | ACE | 0.25 (0.17-0.33) | 0.05 (0.03-0.06) | - | - | 0.70 (0.63-0.78) |
| Parkinson’s | AE | 0.26 (0.20-0.34) | - | - | - | 0.74 (0.72-0.81) |
| Depression | ACE | 0.25 (0.21-0.29) | 0.15 (0.15-0.15) | - | - | 0.60 (0.58-0.63) |
| Lung cancer | ACE | 0.09 (0.02-0.14) | 0.11 (0.09-0.13) | - | - | 0.81 (0.75-0.86) |
| Bowel cancer | ACSE | 0.24 (0.21-0.26) | 0.03 (0.01-0.03) | 0.06 (0.03-0.12) | - | 0.67 (0.65-0.71) |
| Prostate cancer | ASE | 0.38 (0.32-0.44) | - | 0.19 (0.11-0.26) | - | 0.43 (0.36-0.51) |
| Breast cancer | ASE | 0.29 (0.26-0.33) | - | 0.06 (0.01-0.10) | - | 0.65 (0.60-0.69) |
A: Additive genetic effects; C: Environmental effects common to the whole family; S: Sibling environmental effects; P: Partner environmental effects; E: Residual environmental effect; Confidence Interval at 95% between brackets. -: Parameter dropped from parsimonious reduced model.