. Author manuscript; available in PMC: 2018 Jun 6.

Published in final edited form as: Nat Genet. 2016 Jul 18;48(9):980–983. doi: 10.1038/ng.3618

Table 3. Heritability estimates of disease using common + rare SNPs and structural equation modelling (SEM) from self-reported data.

Disease	h²_C+R (CI_95%)	h²_SEM (CI_95%)	%(h² _C+R /h²_SEM) (SE)
Heart Disease	0.11 (0.08-0.15)	0.27 (0.24-0.27)	40.74 (9.79)
Stroke	0.09 (0.00-0.17)	0.23 (0.21-0.25)	39.13 (29.07)
Bronchitis	0.16 (0.10-0.22)	0.29 (0.25-0.33)	54.43 (15.72)
Hypertension	0.32 (0.30-0.34)	0.28 (0.28-0.29)	114.29 (3.29)
Diabetes	0.35 (0.30-0.39)	0.50 (0.49-0.52)	70.00 (5.23)
Depression	0.07 (0.03-0.10)	0.25 (0.23-0.27)	24.00 (13.79)
Bowel cancer	0.12 (0.00-0.28)	0.24 (0.21-0.26)	50.0 (49.75)
Prostate cancer	0.23 (0.06-0.40)	0.38 (0.32-0.44)	60.53 (30.42)
Breast cancer	0.18 (0.10-0.26)	0.29 (0.26-0.33)	62.07 (19.05)

h²_C+R: Heritability estimates using SNPs in the liability scale; (CI_95%): Confidence intervals; %(h²_C+R /h²_SEM): Percentage of SEM family-based estimate of heritability explained by SNPs. (SE): Standard error