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. 2017 Oct 24;1(3):84–96. doi: 10.1002/bjs5.18

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© 2017 The Authors. BJS Open published by John Wiley & Sons Ltd on behalf of British Journal of Surgery Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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BJS5-18-FIG-0003-c — a–d Typical microscopic changes in the future liver remnant after Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) and portal vein ligation (PVL) (haematoxylin and eosin stain, magnification ×400; scale bars 50 μm): a hepatocyte mitosis – cellular features of extreme hepatocyte hypertrophy and binuclear hepatocytes or polyploidy (arrows); b microvesicular steatosis (arrows); c marked sinusoidal dilatation (arrows); d microvesicular steatosis – atrophic hepatocytes (arrows) and sinusoidal dilatation around central vein. e Sinusoidal injury score on days 1, 3 and 7 after step 1 surgery. Values are mean(s.d.) (4–5 animals per group). *P < 0·050, ALPPS10 versus LLL, ALPPS30 and ALPPS20 (ANOVA); †P < 0·050, ALPPS10 versus PVL (Student's t test)