Table 2.

Cingulo-opercular network function in pediatric obsessive-compulsive disorder (OCD) compared to healthy controls

ERRORS
	pMFC		Left aI/fO		Right aI/fO
Intercept	1.10 ± .28	<.001	1.48 ± .25	<.001	1.42 ± .28	<.001
Group	.98 ± .41	.018	0.50 ± .36	.175	.58 ± .39	.139
Age	−.25 ± .13	.063	------------	---	−.12 ± .13	.342
Inc RT	−.006 ± .002	.001	------------	---	−0.004 ± .002	.025
Inc Acc	10.06 ± 3.07	.002	1.70 ± 3.91	.665	7.1 ± 2.97	.019
Group × Age	.39 ± .18	.029	------------	---	.28 ± .17	.098
Group × Inc RT	.005 ± .002	.026	------------	---	.006 ± .002	.010*
Group × Inc Acc	------------	---	8.13 ± 5.41	.136	------------	---
Motion	------------	---	−3.38 ± 1.60	.037	------------	---
Adjusted R-Square	0.17		0.08		0.08
Model ANOVA	F(6,95)=4.4 (p<.001)		F(4,97)=3.2 (p=.016)		F (6,95) = 2.5 (p=.03)
INTERFERENCE
	pMFC		Left aI/fO		Right aI/fO
Intercept	.60 ± .07	<.001	.45 ± .08	<.001	.52 ± .08	<.001
Group	−.02 ± .10	.847	−.08 ± .12	.492	−.10 ± .12	.413
Age	------------	----	------------	----	------------	----
Overall RT	−.001 ± .0004	.055	−.001 ±.0004	.053	−.001 ± .0003	.001*
Overall Acc	1.41 ± 1.76	.425	4.93 ± 2.04	.017*	1.77 ± 2.06	.393
Group × Age	------------	----	------------	----	------------	----
Group × overall RT	.001 ± .0005	.028	.001 ± .0006	.100	------------	----
Group × overall Acc	−5.17 ± 2.51	.042	−7.83 ± 2.9	.008*	−4.90 ± 2.95	.099
Motion	------------	---	------------	---	------------	---
Adjusted R-Square	0.03		0.05		0.08
Model ANOVA*	F(5,135)= 2.0 (p=.086)		F(5,135)=2.4 (p=.039)		F(4,136)=4.2 (p=.003)

Note: Motion refers to framewise displacement ²⁸. Dashed lines represent predictor variables eliminated during backwards stepwise regression.

Significance levels were p < .05 for pMFC (primary region of interest, bolded) and p < .013 for secondary ROIs (asterisked).

aI/fO = anterior insula/frontal operculum, Acc = accuracy, Inc = incongruent, HC = healthy controls, pMFC = posterior medial frontal cortex, RT = response time