Table 2. Top 5 most significant Gene Ontology (GO) categories (i.e. Biological Process, Molecular Function, Cellular Component) belonging to the red, purple and combined green profiles, as determined by STEM.

Category ID		Category Name	#Genes Category		#Genes Assigned					#Genes Expected			#Genes Enriched		p-value			Corrected p-value*
RED PROFILE
GO:0031012		extracellular matrix	157		125					64.5			60.5		9.70E-25			4.30E-21
GO:0072359		circulatory system development	229		162					94			68		4.30E-22			1.90E-18
GO:0005578		proteinaceous extracellular matrix	129		103					53			50		1.50E-20			6.80E-17
GO:0072358		cardiovascular system development	175		129					71.8			57.2		4.80E-20			2.20E-16
GO:0001944		vasculature development	175		129					71.8			57.2		4.80E-20			2.20E-16
PURPLE PROFILE
GO:0007416	synapse assembly			28		11		3.1			7.9			8.10E-05		0.363
GO:0022607	cellular component assembly			307		52		33.5			18.5			3.10E-04		1
GO:0044085	cellular component biogenesis			317		52		34.6			17.4			7.20E-04		1
GO:0050808	synapse organization			45		12		4.9			7.1			2.30E-03		1
GO:0031514	motile cilium			10		5		1.1			3.9			2.30E-03		1
COMBINED GREEN PROFILES
GO:0005654		nucleoplasm		197			87		59.6			27.4		9.50E-06			0.043
GO:0031981		nuclear lumen		253			105		76.5			28.5		3.10E-05			0.139
GO:0070013		intracellular organelle lumen		279			114		84.4			29.6		3.10E-05			0.139
GO:0043233		organelle lumen		279			114		84.4			29.6		3.10E-05			0.139
GO:0044428		nuclear part		286			114		86.5			27.5		1.20E-04			0.517

*Bonferroni correction