Table 1. Characteristics of included studies in the final meta-analysis.

Name	Year	Cancer type	Region	Ethnicity	Design	Genotype	Case				Control				MAF	HWE	Score
						method	GG	CG	CC	All	GG	CG	CC	All
Feng	2016	Gastric	China	Asian	HB	PCR-RFLP	47	85	45	177	84	107	46	237	0.42	0.260	6
Ma	2016	Breast	China	Asian	HB	PCR-RFLP	116	145	59	320	84	107	46	237	0.42	0.260	7
Du	2016	Colorectal	China	Asian	HB	TaqMan	286	459	133	878	355	405	124	884	0.37	0.623	9
Wang	2015	Breast	China	Asian	HB	PCR-RFLP	95	6	0	101	100	1	0	101	0.00	0.960	9
Bahceci	2014	B-NHL	Turkey	Others	PB	AS-PCR	59	33	1	93	43	44	9	96	0.32	0.637	4
Li	2014	Gastric	China	Asian	HB	PCR-RFLP	99	83	36	218	112	82	24	218	0.30	0.135	7
Zhu	2014	Bladder	China	Asian	HB	MassARRAY	62	160	65	287	76	139	67	282	0.48	0.825	6
Lu	2014	Larynx	China	Asian	HB	MassARRAY	53	69	54	176	78	63	36	177	0.38	0.001	8
Liu	2014	Gastric	China	Asian	HB	PCR-RFLP	99	100	39	238	120	95	23	238	0.30	0.510	8
Ruiz-Cosano	2013	BCL	Spain	Caucasian	PB	TaqMan	125	71	17	213	119	81	14	214	0.25	0.965	7
Zeng	2013	Lung	China	Asian	HB	PCR-RFLP	15	77	47	139	35	61	37	133	0.51	0.341	8
Yuan	2012	HNC	China	Asian	PB	TaqMan	108	191	95	393	234	433	217	884	0.49	0.552	12
Biason	2012	Osteosarcoma	Italy	Caucasian	HB	PCR-RFLP	75	39	16	130	141	94	15	250	0.25	0.899	8
Gil	2012	Colorectal	Poland	Caucasian	HB	PCR-RFLP	86	35	11	132	64	31	5	100	0.21	0.625	6
Berhane	2012	Prostate	India	Asian	PB	PCR-RFLP	58	72	20	150	66	75	9	150	0.31	0.039	8
Ma	2012	HNC	America	Caucasian	PB	SNPlex	648	359	52	1059	654	350	62	1066	0.22	0.099	10
Rouissi	2011	Bladder	Tunisia	African	PB	PCR	48	56	21	125	46	61	18	125	0.39	0.758	6
Ibarrola-Villava	2011	Melanoma	Spain	Caucasian	HB	TaqMan	326	222	50	598	215	140	24	379	0.25	0.85	5
Canbay	2011	Colorectal	Turkey	Others	PB	PCR-RFLP	43	34	2	79	148	83	16	247	0.23	0.352	10
Goncalves	2011	Melanoma	Brazil	Caucasian	HB	PCR-RFLP	105	77	10	192	109	74	25	208	0.30	0.031	9
Doherty	2011	Endometrial	America	Others	PB	Unknown	418	254	42	714	408	248	47	703	0.24	0.268	10
Hsu	2010	Breast	China	Asian	HB	TaqMan	76	191	134	401	129	243	159	531	0.53	0.059	8
Figl	2010	Melanoma	German, Spain	Caucasian	PB	TaqMan	703	409	74	1186	725	465	84	1274	0.25	0.420	8
Canbay	2010	Gastric	Turkey	Others	PB	PCR-RFLP	25	12	3	40	148	83	16	247	0.23	0.352	8
Li	2010	HCC	China	Asian	HB	TaqMan	174	233	93	500	151	265	91	507	0.44	0.175	11
Narter	2009	Bladder	Turkey	Others	PB	PCR-RFLP	25	28	3	56	18	19	3	40	0.31	0.505	5
Abbasi	2009	Larynx	Germany	Caucasian	PB	Real-time PCR	137	103	8	248	380	230	37	647	0.23	0.778	11
Hussain	2009	Gastric	China	Asian	PB	SNPlex	38	105	38	181	90	180	90	360	0.50	1.000	12
El-Zein	2009	HD	America	Caucasian	PB	TaqMan	104	78	16	198	127	80	12	219	0.24	0.897	10
McKean-Cowdin	2009	Brain	America	Caucasian	Mixed	TaqMan and MassARRAY	499	348	157	1004	989	657	311	1957	0.33	0.000	13
Pan	2009	Esophageal	America	Caucasian	HB	TaqMan	201	131	12	344	287	155	15	457	0.20	0.281	7
Rajaraman	2008	Breast	America	Others	PB	TaqMan	482	288	49	819	674	352	53	1079	0.21	0.423	13
Chang	2008	Lung	America	Africa American	PB	Illumina	68	119	68	255	93	138	49	280	0.42	0.858	8
Chang	2008	Lung	America	Latino	PB	Illumina	60	44	9	113	138	127	34	299	0.33	0.561	7
Pardini	2008	Colorectal	Czech	Caucasian	HB	PCR-RFLP	334	177	21	532	356	153	23	532	0.19	0.211	11
Smith	2008	Breast	America	African American	PB	MassARRAY	13	32	7	52	18	37	20	75	0.51	0.913	9
Hung	2008	Lung	World	World	Mixed	Unknown	1852	1155	209	3216	2485	1510	286	4281	0.24	0.006	10
He	2008	Cervical	China	Asian	HB	mismatch amplification PCR	71	94	35	200	67	80	53	200	0.47	0.006	8
Hooker	2008	Prostate	America	African	HB	PCR	74	119	61	254	99	142	60	301	0.44	0.484	8
Wang	2007	NMSC	Texas	Caucasian	HB	PCR	146	89	11	246	200	119	10	329	0.21	0.121	8
Povey	2007	Melanoma	Scotland	Caucasian	PB	PCR-RFLP	314	169	24	507	252	162	27	441	0.24	0.887	13
Crew	2007	Breast	America	Others	PB	Sequenom	562	371	66	999	571	409	71	1051	0.26	0.846	11
An	2007	HNC	America	Caucasian	HB	PCR	507	286	36	829	519	289	46	854	0.22	0.489	11
Jorgensen	2007	Breast	America	Others	PB	TaqMan	159	93	12	264	165	95	15	275	0.23	0.785	10
Mechanic	2006	Breast	America	African American	PB	TaqMan	231	387	139	757	231	320	123	674	0.42	0.509	9
Mechanic	2006	Breast	America	Caucasian	PB	TaqMan	771	409	69	1249	661	412	60	1133	0.23	0.685	9
Shen	2006	Breast	America	Others	PB	TaqMan	83	63	8	154	82	62	7	151	0.25	0.268	11
Sugimura	2006	OSCC	Japan	Asian	HB	PCR-RFLP	43	59	20	122	77	112	52	241	0.45	0.348	5
Garcia-Closas	2006	Bladder	Spain	Caucasian	HB	Sequencing	629	434	78	1141	607	445	84	1136	0.27	0.844	11
Li	2006	Melanoma	America	Caucasian	HB	PCR	373	206	23	602	370	206	27	603	0.22	0.805	12
Wu	2006	Bladder	America	Others	PB	TaqMan	364	225	26	615	371	211	18	600	0.21	0.064	13
Thirumaran	2006	BCC	Hungry, Romania, Slovakia	Caucasian	HB	TaqMan	325	172	32	529	330	173	30	533	0.22	0.250	11
Shen	2006	NHL	America	Others	PB	TaqMan	260	170	34	464	352	169	29	550	0.21	0.146	13
Le Morvan	2006	Sarcoma	France	Caucasian	HB	PCR-RFLP	182	107	19	308	31	21	1	53	0.22	0.227	6
Sakiyama	2005	Lung	Japan	Asian	Mixed	Pyrosequencing	300	500	202	1002	228	333	124	685	0.42	0.900	7
Shen	2005	Lung	China	Asian	PB	TaqMan	38	52	26	116	38	46	25	109	0.44	0.133	10
Weiss	2005	Endometrial	America	Caucasian	PB	PCR-RFLP	215	134	22	371	250	148	22	420	0.23	0.987	11
Blankenburg	2005	Melanoma	German	Caucasian	PB	PCR-RFLP	9	100	184	293	18	124	232	374	0.79	0.785	8
Sanyal	2004	Bladder	Sweden	Caucasian	PB	PCR-RFLP	182	109	8	299	173	91	20	284	0.23	0.102	8
Kumar	2003	Breast	Finland	Caucasian	PB	PCR-RFLP	108	96	16	220	182	107	19	308	0.24	0.540	10

MAF, minor allele frequency; HWE, Hardy-Weinberg equilibrium; B-NHL, B cell non-Hodgkin's lymphoma; BCL, B cell lymphoma; HNC, head and neck cancer; HCC, hepatocellular carcinoma; HD, Hodgkin’s disease; NMSC, non-melanoma skin cancer; OSCC, oral squamous cell carcinoma; BCC, basal cell carcinoma; HB, hospital based; PB, population based; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; AS-PCR, allele-specific PCR.