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The functions of E2Fs and genes significant associated with E2Fs alterations were predicted by analysis of Gene Ontology (GO) by DAVID (Database for Annotation, Visualization, and Integrated Discovery) tools (https://david.ncifcrf.gov/summary.jsp). GO enrichment analysis predicted the functional roles of target host genes based on three aspects including biological processes (A), cellular components (B), and molecular functions (C).
